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February 01 2018

Zeroing in on dopamine

Scientists have identified the molecular machinery responsible for secretion of the neurotransmitter dopamine, opening the door for strategies to precision target dopamine release to treat disorders such as Parkinson's and addiction.

Food preservative enhances schizophrenia treatment

A randomized, double-blind, placebo-controlled trial shows that sodium benzoate improves symptoms in clozapine-resistant schizophrenia.

January 31 2018

Molecular secrets revealed: Antipsychotic docked in its receptor

Scientists have deciphered the molecular structure of a widely prescribed antipsychotic docked in its key receptor. They are hopeful that this discovery may hold secrets to designing better treatments for schizophrenia, bipolar disorder, and other mental illnesses.

January 24 2018

Breakthrough could lead to better antipsychotic drugs

Although antipsychotic drugs are among the most widely prescribed medications, individuals with schizophrenia, bipolar disorder and autism-spectrum disorders often experience severe side effects because the drugs interact with dozens of other brain receptors. Now, scientists have solved the first high-resolution crystal structure of the dopamine 2 receptor (DRD2) bound to the antipsychotic drug risperidone, yielding a long-awaited tool for drug developers, psychiatrists, and neuroscientists.

January 18 2018

Postmortem schizophrenia study identifies shifts in patterns of glutamate and GABA in visuospatial working memory network

Disruptions in certain regions of the visuospatial working memory network may lead to its impairment in schizophrenia, according to a new study.

January 03 2018

Rare forms of 'thunder' protein may be linked to schizophrenia

Researchers report they have identified rare genetic variations in a protein called Thorase, which is responsible for breaking down receptors at the connections between neurons in the brain.

December 13 2017

Treatable Condition Could Be Mistaken for Schizophrenia or Bipolar Disorder

Researchers believe that a significant number of people diagnosed with schizophrenia or bipolar disorder may actually have a treatable immune system condition. A new research study could have a significant impact on the millions diagnosed with schizophrenia or bipolar disorder, including many homeless.

December 12 2017

New therapy can help schizophrenia sufferers re-engage socially

A new therapy aimed at helping young people suffering from schizophrenia to reconnect and engage with the world around them has had promising results, according to a new study.

December 11 2017

Updated brain cell map connects various brain diseases to specific cell types

Researchers have developed new single-cell sequencing methods that could be used to map the cell origins of various brain disorders, including Alzheimer's, Parkinson's, schizophrenia and bipolar disorder. By analyzing individual nuclei of cells from adult human brains, researchers have identified 35 different subtypes of neurons and glial cells and discovered which of these subtypes are most susceptible to common risk factors for different brain diseases.

December 08 2017

How individuals with schizophrenia view their experiences and confidence in judgments may influence treatment targets

A schizophrenia patient's own perceptions of their experiences -- and confidence in their judgments -- may be factors that can help them overcome challenges to get the life they wish, suggests a new paper.

December 04 2017

Right-handed or left-handed? Hand preference during gestation

Are you born or do you become right-handed or left-handed? A study shows that hand preference is already well defined at the 18th gestational week. The predictive capacity of the method used seems a good starting point for the early recognition of pathologies characterized by cerebral asymmetries, such as depression, schizophrenia and autism spectrum disorders.

November 24 2017

Avatar therapy may help to reduce auditory hallucinations for people with schizophrenia

An experimental therapy which involves a face-to-face discussion between a person with schizophrenia and an avatar representing their auditory hallucination may help reduce symptoms, when provided alongside usual treatment, according to a study.

November 22 2017

Schizophrenia drug development may be 'de-risked' with new research tool

Biomarkers that can help with development of better treatments for schizophrenia have now been identified, report investigators.

November 13 2017

Innovative genetic, cellular techniques help identify multiple disease targets

Advances in the use of CRISPR-Cas9 and human induced pluripotent stem cell technologies to identify novel therapeutic targets for neurological disorders such as schizophrenia and addiction have been highlighted by researchers.

November 08 2017

Gene breakthrough on lithium treatment for bipolar disorder

Genes linked to schizophrenia in psychiatric patients suffering from bipolar disorder are the reason why such patients don't respond to the "gold standard" treatment for bipolar -- the drug lithium -- according to international research.

October 23 2017

Introduction of a novel system for in vitro analyses of zebrafish oligodendrocyte progenitor cells

Spinal cord injuries result from a blunt or penetrating trauma. This is generally caused by accidents that occur during sport activities or when driving. Injuries of the spinal cord can lead to extreme pain (e.g. pressure in the head, neck or back), the loss of sensation (e.g. in fingers or feet), the loss of control over different parts of the body, an abnormal sense of balance and many other symptoms. According to the World Health Organization (WHO), as many as 500,000 people suffer from spinal cord injuries each year. Humans do not regain spinal cord function after injury. However, zebrafish have the remarkable ability to functionally recover from spinal cord injury. They repair injured connections, replace damaged motor neurons and oligodendrocytes, enabling them to regain full movement within six weeks after injury.

October 17 2017

Schizophrenia disrupts the brain's entire communication system, researchers say

Some 40 years since CT scans first revealed abnormalities in the brains of schizophrenia patients, international scientists say the disorder is a systemic disruption to the brain's entire communication system. The study sets the stage for future research on the debilitating mental illness that affects more than 21 million people worldwide. It is the largest analysis of 'white matter' differences in a psychiatric disorder to date.

October 11 2017

Psychologists give new insight into the nature of psychosis

Psychologists challenged common wisdom about the nature of mental illness.

Brain chemical abnormalities in earliest stage of psychosis identified

A new study of young people experiencing a first episode of psychosis reports elevations in the brain chemicals glutamate and glycine.

October 10 2017

Major breakthrough identifies new mechanism for the development of schizophrenia

The new research shows that dysfunctional brain blood vessels may be associated with the development of schizophrenia. There is potential for new treatments of schizophrenia by developing new drugs to target these abnormal blood vessels.
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